Food allergy (FA) has rapidly increased over the last 2 decades affecting 32 million Americans, with annual costs of $25 billion. FA anaphylaxis, a potentially life-threatening condition, increased 200-400% in children from toddlers to teens, accounting for up to 81% of pediatric anaphylaxis. GNT has developed several treatments for food allergy. These include: 

• Natural compounds that inhibited IgE production. 

• Nano-medicine formulations that deliver the IgE-inhibiting compounds with enhanced bioavailability.  

• Fermented foods and probiotic dietary supplements that reduce food allergy symptoms.

Allergic Asthma is an increasingly common disease in western countries.  There is no preventive or curative treatment. Chronic asthma is associated with persistent inflammation, airway hyperreactivity and airway remodeling. Standard therapy for asthma currently involves suppression of asthmatic immune-responses by glucocorticoids and relief of airway hyperreactivity (AHR) by β-adrenergic agonists. While this approach is widely applied, it does not provide a cure. Maintaining control requires rigorous compliance, with long-term side effects. GNT is developing several alternative treatments for asthma.

Anti-asthma herbal medicine intervention (ASHMI)

ASHMI has been tested in phase I and phase IIa trials. ASHMI showed high safety and tolerability profiles. The combination of ASHMI and inhaled steroid is safe and more effective than steroid alone in children.  

• Experimental research showed that ASHMI is effective in both eosinophilic and corticosteroid-resistant, -neutrophil dominant asthma.

• It inhibits Th2 cytokines and TNF-a, IgE and increase IFN-g, indicating beneficial immune modulatory effects

Natural purified compounds:

• Relax airway smooth muscle

• Reduce eotaxin

Eczema is a common allergic inflammatory skin disorder characterized by itchy, scaly, erythematous, and oozing skin, affecting up to 20% of children and 1% to 3% of adults in most countries. The estimates of US costs range from $364 million to $3.8 billion per year. Allergic Rhinitis, Food Allergy, and Asthma are frequently comorbid with eczema. Furthermore, increased risks of infection, lymphoma, pruritus, and nonmelanoma skin cancer have been reported in patients with atopic dermatitis (AD). Topical corticosteroids (steroids) are the first-line treatment; however, over time, AD becomes steroid refractory in some patients. Approximately 10% of them require one or more systemic treatments. 

Our proprietary Shi Zhen formulations improve skin lesion, reduce peripheral blood eosinophils, and hyper serum IgE.

The National Health and Nutrition Examination Survey revealed that more than one-third of adult Americans were obese in 2009-2010. It is projected that obesity prevalence rates for the United States will be more than 40% by 2025. Obesity is a chronic disease associated with significant morbidity, and has substantial healthcare implications due to increased risk for diseases including hypertension, diabetes, stroke, inflammation disorders and certain cancers. Overweight and obesity rank as the fifth leading risk for death globally. At least 2.8 million adults die each year worldwide as a result of being overweight or obese. 

Weight loss formula (W-LHGT)

1. Herbal therapy for the treatment of food allergy. US7820175B2 

2. Compounds isolated from Chinese medicinal herb Sophora Flavescens that inhibit airway contraction. US10406191B2 

3. Weight loss formulations, methods, and compositions based on traditional Chinese medicine. US10028985B2  

4. Suppression of IgE production by compounds derived from traditional Chinese medicine. US10500169B2   

5. Treatment of immunological disease using berberine nanoparticles. US11351157B2.